Mark O'Brien, MD

Internal Medicine & Nephrology
Grand Rapids, MI 616 774-8200

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Why Choose Dr. O'Brien?


  • Get More Information on Coronavirus (CDC)
  • 24/7 Availability  via  Dedicated Phone or Email
  • Recommendations and/or Referrals to Specialists
  • Management of Your Overall Health Concerns


  • Same or Next Business Day Appointments
  • On Time Appointments That Do Away With Rushed Visits
  • Office Visits for Visiting Friends & Family

Expect More From Personalized Care

As one of a few hundred, rather than one of a few thousand patients, members enjoy more time with and enhanced availability and service from their personalized physician.

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SignatureMD works with the most attentive and
qualified physicians because your health matters to us.
It's more than good business; it's the right thing to do.

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I wouldn’t go anywhere else! One of the nicest Doctor’s you will ever find!

Has taken care of my family for over a year, always a pleasure and he is usually on time which is important to me.

I have an autoimmune disease that was missed by 2 other physicians in his group. Dr. O’Brien spent 30 minutes with me and after a few blood tests not only was I diagnosed but treated and now I am feeling better than I have in years. (more…)

He left Riverview after 1 year, we were very upset. I find out he moved to IU Health. We will be following him there (wife and myself). (more…)

Your Health Is Personal

You're not a commodity, so why accept assembly-line healthcare? Dr. O'Brien's practice is personalized to fit your unique needs and busy schedule. From crafting a personalized healthcare plan with you to accommodating last-minute appointments, your well being is our priority.

Personalize Your Healthcare

Call us, if you prefer! 616 774-8200

Mark O'Brien, MD